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MGP000698

UniProt Annotations

Entry Information
Gene Namec-src tyrosine kinase
Protein EntryCSK_HUMAN
UniProt IDP41240
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE- ProRule:PRU10028}.
DomainThe architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain.
FunctionNon-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. {ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:9281320}.
InteractionSelf; NbExp=7; IntAct=EBI-1380630, EBI-1380630; P08069:IGF1R; NbExp=5; IntAct=EBI-1380630, EBI-475981; P08575:PTPRC; NbExp=3; IntAct=EBI-1380630, EBI-1341; P49023:PXN; NbExp=2; IntAct=EBI-1380630, EBI-702209; P00523:SRC (xeno); NbExp=6; IntAct=EBI-1380630, EBI-848039;
PtmPhosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated. {ECO:0000269|PubMed:11181701, ECO:0000269|PubMed:9148770}.
SimilarityBelongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. {ECO:0000255|PROSITE- ProRule:PRU00159}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
SimilarityContains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
SimilarityContains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular LocationCytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}.
SubunitHomodimer (via SH3-domain). Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and inhibit Src-family kinases. Interacts with SRCIN1. Interacts with RHOH. Interacts (via SH2 domain) with SCIMP. {ECO:0000250, ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:10838081, ECO:0000269|PubMed:11433379, ECO:0000269|PubMed:14610046, ECO:0000269|PubMed:17525734, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21930792}.
Tissue SpecificityExpressed in lung and macrophages. {ECO:0000269|PubMed:1371489}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/csk/";
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