MGP Database

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MGP000706

Ontology/Pathway Information

Entrez Gene ID1462
Gene Nameversican
Gene Symbol VCAN
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031012 IDA:UniProtKBCextracellular matrix
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0005796 TAS:ReactomeCGolgi lumen
GO:0043231 IDA:HPACintracellular membrane-bounded organelle
GO:0043202 TAS:ReactomeClysosomal lumen
GO:0016020 IDA:UniProtKBCmembrane
GO:0005578 TAS:ProtIncCproteinaceous extracellular matrix
GO:0005509 IEA:InterProFcalcium ion binding
GO:0030246 IEA:UniProtKB-KWFcarbohydrate binding
GO:0005539 TAS:ProtIncFglycosaminoglycan binding
GO:0005540 TAS:ProtIncFhyaluronic acid binding
GO:0005975 TAS:ReactomePcarbohydrate metabolic process
GO:0007155 TAS:ProtIncPcell adhesion
GO:0008037 TAS:ProtIncPcell recognition
GO:0030206 TAS:ReactomePchondroitin sulfate biosynthetic process
GO:0030207 TAS:ReactomePchondroitin sulfate catabolic process
GO:0030204 TAS:ReactomePchondroitin sulfate metabolic process
GO:0030208 TAS:ReactomePdermatan sulfate biosynthetic process
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0008347 IDA:BHF-UCLPglial cell migration
GO:0030203 TAS:ReactomePglycosaminoglycan metabolic process
GO:0007507 IEA:EnsemblPheart development
GO:0007275 TAS:ProtIncPmulticellular organismal development
GO:0001649 IDA:UniProtKBPosteoblast differentiation
GO:0044281 TAS:ReactomePsmall molecule metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_121408A tetrasaccharide linker sequence is required for GAG synthesis
REACT_120989Chondroitin sulfate biosynthesis
REACT_121206Chondroitin sulfate/dermatan sulfate metabolism
REACT_120888CS/DS degradation
REACT_268678Defective B3GAT3 causes JDSSDHD
REACT_268431Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
REACT_268749Defective B4GALT7 causes EDS, progeroid type
REACT_267917Defective CHST14 causes EDS, musculocontractural type
REACT_267648Defective CHST3 causes SEDCJD
REACT_268786Defective CHST6 causes MCDC1
REACT_268113Defective CHSY1 causes TPBS
REACT_267942Defective EXT1 causes exostoses 1, TRPS2 and CHDS
REACT_267741Defective EXT2 causes exostoses 2
REACT_268843Defective PAPSS2 causes SEMD-PA
REACT_268059Defective SLC26A2 causes chondrodysplasias
REACT_120800Dermatan sulfate biosynthesis
REACT_116125Disease
REACT_268624Diseases associated with glycosaminoglycan metabolism
REACT_268324Diseases of glycosylation
REACT_163906ECM proteoglycans
REACT_118779Extracellular matrix organization
REACT_264090Glycogen storage diseases
REACT_121315Glycosaminoglycan metabolism
REACT_121314Heparan sulfate/heparin (HS-GAG) metabolism
REACT_111217Metabolism
REACT_474Metabolism of carbohydrates
REACT_147857MPS I - Hurler syndrome
REACT_147734MPS II - Hunter syndrome
REACT_147753MPS IIIA - Sanfilippo syndrome A
REACT_147788MPS IIIB - Sanfilippo syndrome B
REACT_147860MPS IIIC - Sanfilippo syndrome C
REACT_147749MPS IIID - Sanfilippo syndrome D
REACT_147825MPS IV - Morquio syndrome A
REACT_147798MPS IV - Morquio syndrome B
REACT_147739MPS IX - Natowicz syndrome
REACT_147759MPS VII - Sly syndrome
REACT_147719MPS VI - Maroteaux-Lamy syndrome
REACT_147853Mucopolysaccharidoses
REACT_264430Myoclonic epilepsy of Lafora
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