MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000706

UniProt Annotations

Entry Information
Gene Nameversican
Protein EntryCSPG2_HUMAN
UniProt IDP13611
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=V0; IsoId=P13611-1; Sequence=Displayed; Name=V1; IsoId=P13611-2; Sequence=VSP_003082, VSP_003083; Name=V2; IsoId=P13611-3; Sequence=VSP_003084; Name=V3; IsoId=P13611-4; Sequence=VSP_003082, VSP_003085; Name=Vint; IsoId=P13611-5; Sequence=VSP_003086;
Developmental StageDisappears after the cartilage development.
DiseaseWagner vitreoretinopathy (WGVRP) [MIM:143200]: A rare vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. {ECO:0000269|PubMed:16043844, ECO:0000269|PubMed:22739342}. Note=The disease is caused by mutations affecting the gene represented in this entry. The pathological mechanism involves a quantitave imbalance of the normally occurring splice variants (PubMed:22739342). {ECO:0000269|PubMed:22739342}.
FunctionMay play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
InteractionP14780:MMP9; NbExp=3; IntAct=EBI-8515977, EBI-1382326;
PtmPhosphorylation sites are present in the extracellular medium.
SimilarityBelongs to the aggrecan/versican proteoglycan family. {ECO:0000305}.
SimilarityContains 1 C-type lectin domain. {ECO:0000255|PROSITE- ProRule:PRU00040}.
SimilarityContains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
SimilarityContains 1 Sushi (CCP/SCR) domain. {ECO:0000255|PROSITE-ProRule:PRU00302}.
SimilarityContains 2 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}.
SimilarityContains 2 Link domains. {ECO:0000255|PROSITE- ProRule:PRU00323}.
Subcellular LocationSecreted, extracellular space, extracellular matrix.
SubunitInteracts with FBLN1. {ECO:0000250}.
Tissue SpecificityCerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/VCANID40173ch5q14.html";
Web ResourceName=Functional Glycomics Gateway - Glycan Binding; Note=Versican; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_214";
  logo