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MGP000730

Record overview

MGPD IDMGP000730
Gene ID1512
SpeciesHomo sapiens (Human)
Gene Namecathepsin H
Gene Symbol CTSH
SynonymsCPSB; ACC-4; ACC-5; minichain;
Alternate namespro-cathepsin H; aleurain; cathepsin B3; cathepsin BA; N-benzoylarginine-beta-naphthylamide hydrolase;
Chromosome15
Map Location15q25.1
EC Number3.4.22.16
SummaryThe protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for CTSH

Proteins

pro-cathepsin H preproprotein
Refseq ID:NP_004381
Protein GI:23110955
UniProt ID:P09668
mRNA ID:NM_004390
Length:335
RefSeq Status:
MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQ
NCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIM
GEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVK
NSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
 
sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2243
peptide sequence: 
MWATLPLLCAGAWLLGVPVCGA

mat_peptide: 116..335
product: cathepsin H
calculated_mol_wt: 24162
peptide sequence: 
YPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCK
FQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLI
ERGKNMCGLAACASYPIPLV

mat_peptide: 116..292
product: cathepsin H heavy chain
calculated_mol_wt: 19377
peptide sequence: 
YPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCK
FQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKN

mat_peptide: 293..335
product: cathepsin H light chain
calculated_mol_wt: 4803
peptide sequence: 
GIPYWIVKNSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
 
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