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MGP000730

UniProt Annotations

Entry Information

Gene Name	cathepsin H
Protein Entry	CATH_HUMAN
UniProt ID	P09668
Species	Human

Comments

Comment type	Description
Catalytic Activity	Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-\|-Xaa bonds) as well as an endopeptidase.
Function	Important for the overall degradation of proteins in lysosomes.
Similarity	Belongs to the peptidase C1 family. {ECO:0000255\|PROSITE-ProRule:PRU10088, ECO:0000255\|PROSITE- ProRule:PRU10089, ECO:0000255\|PROSITE-ProRule:PRU10090}.
Subcellular Location	Lysosome.
Subunit	Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CTSHID40206ch15q25.html";