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MGP000731

Record overview

MGPD IDMGP000731
Gene ID1513
SpeciesHomo sapiens (Human)
Gene Namecathepsin K
Gene Symbol CTSK
SynonymsCTSO; PKND; PYCD; CTS02; CTSO1; CTSO2;
Alternate namescathepsin K; cathepsin O; cathepsin X; cathepsin O1; cathepsin O2;
Chromosome1
Map Location1q21
EC Number3.4.22.38
SummaryThe protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
OrthologsView orthologs and multiple alignments for CTSK

Proteins

cathepsin K preproprotein
Refseq ID:NP_000387
Protein GI:4503151
UniProt ID:P43235
mRNA ID:NM_000396
Length:329
RefSeq Status:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHS
RSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDA
YPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
 
sig_peptide: 1..15
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1673
peptide sequence: 
MWGLKVLLLPVVSFA

mat_peptide: 115..329
product: Cathepsin K
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P43235.1)
calculated_mol_wt: 23496
peptide sequence: 
APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNP
TGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNK
NNACGIANLASFPKM
 
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