MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000733

Record overview

MGPD IDMGP000733
Gene ID1515
SpeciesHomo sapiens (Human)
Gene Namecathepsin V
Gene Symbol CTSV
SynonymsCTSU; CATL2; CTSL2;
Alternate namescathepsin L2; cathepsin U; cathepsin L2, preproprotein;
Chromosome9
Map Location9q22.2
EC Number3.4.22.43
SummaryThe protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]
OrthologsView orthologs and multiple alignments for CTSV

Proteins

cathepsin L2 preproprotein
Refseq ID:NP_001324
Protein GI:23110960
UniProt ID:O60911
mRNA ID:NM_001333
Length:334
RefSeq Status:
MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKF
RKGKVFREPLFLDLPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEE
SYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1694
peptide sequence: 
MNLSLVLAAFCLGIASA

sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1694
peptide sequence: 
MNLSLVLAAFCLGIASA
 
cathepsin L2 preproprotein
Refseq ID:NP_001188504
Protein GI:320118898
UniProt ID:O60911
mRNA ID:NM_001201575
Length:334
RefSeq Status:
Protein sequence is identical to GI:23110960 (mRNA isoform)
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1694
peptide sequence: 
MNLSLVLAAFCLGIASA
 
  logo