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MGP000733

UniProt Annotations

Entry Information
Gene Namecathepsin V
Protein EntryCATL2_HUMAN
UniProt IDO60911
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityThe recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg- NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec). {ECO:0000269|PubMed:10029531}.
FunctionCysteine protease. May have an important role in corneal physiology. {ECO:0000269|PubMed:10029531, ECO:0000269|PubMed:9727401}.
SimilarityBelongs to the peptidase C1 family. {ECO:0000255|PROSITE-ProRule:PRU10088, ECO:0000255|PROSITE- ProRule:PRU10089, ECO:0000255|PROSITE-ProRule:PRU10090}.
Subcellular LocationLysosome {ECO:0000305}.
Tissue SpecificityPredominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin. {ECO:0000269|PubMed:10029531, ECO:0000269|PubMed:9563472, ECO:0000269|PubMed:9727401}.
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