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MGP000735

UniProt Annotations

Entry Information
Gene Namecathepsin S
Protein EntryCATS_HUMAN
UniProt IDP25774
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P25774-1; Sequence=Displayed; Name=2; IsoId=P25774-2; Sequence=VSP_042712; Note=No experimental confirmation available.;
Catalytic ActivitySimilar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val- Arg-|-Xaa compound.
FunctionThiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
SimilarityBelongs to the peptidase C1 family. {ECO:0000255|PROSITE-ProRule:PRU10088, ECO:0000255|PROSITE- ProRule:PRU10089, ECO:0000255|PROSITE-ProRule:PRU10090}.
Subcellular LocationLysosome.
SubunitMonomer. {ECO:0000269|PubMed:17469812}.
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