MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000736

Record overview

MGPD IDMGP000736
Gene ID1522
SpeciesHomo sapiens (Human)
Gene Namecathepsin Z
Gene Symbol CTSZ
SynonymsCTSX;
Alternate namescathepsin Z; cathepsin P; cathepsin X; cathepsin Y; cathepsin B2; cathepsin IV; cathepsin Z1; preprocathepsin P; carboxypeptidase LB; lysosomal carboxypeptidase B; cysteine-type carboxypeptidase;
Chromosome20
Map Location20q13.32
EC Number3.4.18.1
SummaryThe protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
OrthologsView orthologs and multiple alignments for CTSZ

Proteins

cathepsin Z preproprotein
Refseq ID:NP_001327
Protein GI:22538442
UniProt ID:Q9UBR2
mRNA ID:NM_001336
Length:303
RefSeq Status:
MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSA
MADRINIKRKGAWPSTLLSVQNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGRE
KMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGD
PIV
 
sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2417
peptide sequence: 
MARRGPGWRPLLLLVLLAGAAQG

mat_peptide: 62..303
product: cathepsin Z
calculated_mol_wt: 27149
peptide sequence: 
LPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKD
QECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRN
SWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV
 
  logo