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MGP000738

Record overview

MGPD IDMGP000738
Gene ID1524
SpeciesHomo sapiens (Human)
Gene Namechemokine (C-X3-C motif) receptor 1
Gene Symbol CX3CR1
SynonymsV28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1;
Alternate namesCX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1;
Chromosome3
Map Location3p21.3
SummaryFractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
OrthologsView orthologs and multiple alignments for CX3CR1

Proteins

CX3C chemokine receptor 1 isoform a
Refseq ID:NP_001164645
Protein GI:283837934
UniProt ID:P49238
mRNA ID:NM_001171174
Length:387
RefSeq Status:
MREPLEAFKLADLDFRKSSLASGWRMASGAFTMDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSVIFAIGLVGNLLVVFALTNSKKPKSVTDI
YLLNLALSDLLFVATLPFWTHYLINEKGLHNAMCKFTTAFFFIGFFGSIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAAPQFMFT
KQKENECLGDYPEVLQEIWPVLRNVETNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPSCDMR
KDLRLALSVTETVAFSHCCLNPLIYAFAGEKFRRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRHGSVLSSNFTYHTSDGDALLLL
 
CX3C chemokine receptor 1 isoform b
Refseq ID:NP_001164642
Protein GI:283837924
UniProt ID:P49238
mRNA ID:NM_001171171
Length:355
RefSeq Status:
MDQFPESVTENFEYDDLAEACYIGDIVVFGTVFLSIFYSVIFAIGLVGNLLVVFALTNSKKPKSVTDIYLLNLALSDLLFVATLPFWTHYLINEKGLHNA
MCKFTTAFFFIGFFGSIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAAPQFMFTKQKENECLGDYPEVLQEIWPVLRNVETNFLGF
LLPLLIMSYCYFRIIQTLFSCKNHKKAKAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPSCDMRKDLRLALSVTETVAFSHCCLNPLIYAFAGEKF
RRYLYHLYGKCLAVLCGRSVHVDFSSSESQRSRHGSVLSSNFTYHTSDGDALLLL
 
CX3C chemokine receptor 1 isoform b
Refseq ID:NP_001164643
Protein GI:283837927
UniProt ID:P49238
mRNA ID:NM_001171172
Length:355
RefSeq Status:
Protein sequence is identical to GI:283837924 (mRNA isoform)
 
CX3C chemokine receptor 1 isoform b
Refseq ID:NP_001328
Protein GI:4503171
UniProt ID:P49238
mRNA ID:NM_001337
Length:355
RefSeq Status:
Protein sequence is identical to GI:283837924 (mRNA isoform)
 
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