MGP Database

MGP000738

Ontology/Pathway Information

Entrez Gene ID	1524
Gene Name	chemokine (C-X3-C motif) receptor 1
Gene Symbol	CX3CR1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005887	TAS:ProtInc	C	integral component of plasma membrane
GO:0032809	IEA:Ensembl	C	neuronal cell body membrane
GO:0043005	IEA:Ensembl	C	neuron projection
GO:0048471	IEA:Ensembl	C	perinuclear region of cytoplasm
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0004950	TAS:ProtInc	F	chemokine receptor activity
GO:0016495	IEA:Ensembl	F	C-X3-C chemokine receptor activity
GO:0007155	TAS:ProtInc	P	cell adhesion
GO:0006968	TAS:ProtInc	P	cellular defense response
GO:0071222	IEA:Ensembl	P	cellular response to lipopolysaccharide
GO:0071560	IEA:Ensembl	P	cellular response to transforming growth factor beta stimulus
GO:0021795	IEA:Ensembl	P	cerebral cortex cell migration
GO:0070098	TAS:GOC	P	chemokine-mediated signaling pathway
GO:0006935	TAS:ProtInc	P	chemotaxis
GO:0007186	TAS:ProtInc	P	G-protein coupled receptor signaling pathway
GO:0048246	IEA:Ensembl	P	macrophage chemotaxis
GO:0002282	IEA:Ensembl	P	microglial cell activation involved in immune response
GO:0016525	IEA:Ensembl	P	negative regulation of angiogenesis
GO:0030336	IEA:Ensembl	P	negative regulation of cell migration
GO:2001240	IEA:Ensembl	P	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0045766	IEA:Ensembl	P	positive regulation of angiogenesis
GO:0009611	TAS:ProtInc	P	response to wounding
GO:0016032	IEA:UniProtKB-KW	P	viral process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_15344	Chemokine receptors bind chemokines
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_14819	Peptide ligand-binding receptors
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction