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MGP000755

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 2, subfamily C, polypeptide 9
Protein EntryCP2C9_HUMAN
UniProt IDP11712
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P11712-1; Sequence=Displayed; Name=2; IsoId=P11712-2; Sequence=VSP_055573, VSP_055574; Note=No experimental confirmation available.;
Catalytic Activity(+)-(R)-limonene + NADPH + O(2) = (+)-trans- carveol + NADP(+) + H(2)O.
Catalytic Activity(-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O.
Catalytic Activity(-)-(S)-limonene + NADPH + O(2) = (-)-trans- carveol + NADP(+) + H(2)O.
CofactorName=heme; Xref=ChEBI:CHEBI:30413;
FunctionCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan.
InductionBy rifampicin.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP2C9 alleles; URL="http://www.cypalleles.ki.se/cyp2c9.htm";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyp2c9/";
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