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MGP000756

Record overview

MGPD IDMGP000756
Gene ID1562
SpeciesHomo sapiens (Human)
Gene Namecytochrome P450, family 2, subfamily C, polypeptide 18
Gene Symbol CYP2C18
SynonymsCPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C;
Alternate namescytochrome P450 2C18; (S)-mephenytoin hydroxylase associated cytochrome P450; CYPIIC18; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18; cytochrome P450-6B/29C; flavoprotein-linked monooxygenase; microsomal monooxygenase; unspecific monooxygenase;
Chromosome10
Map Location10q24
EC Number1.14.14.1
SummaryThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CYP2C18

Proteins

cytochrome P450 2C18 isoform 1 precursor
Refseq ID:NP_000763
Protein GI:13699816
UniProt ID:P33260
mRNA ID:NM_000772
Length:490
RefSeq Status:
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSF
PVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEK
FNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE
TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKE
FPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV
 
sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2723
peptide sequence: 
MDPAVALVLCLSCLFLLSLWRQSSG

sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2723
peptide sequence: 
MDPAVALVLCLSCLFLLSLWRQSSG
 
cytochrome P450 2C18 isoform 2 precursor
Refseq ID:NP_001122397
Protein GI:193083148
UniProt ID:P33260
mRNA ID:NM_001128925
Length:431
RefSeq Status:
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSF
PVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEK
FNENLRILSSPWIQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYI
DLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLK
SQVDPKDIDITPIANAFGRVPPLYQLCFIPV
 
sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2723
peptide sequence: 
MDPAVALVLCLSCLFLLSLWRQSSG
 
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