MGP Database

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MGP000756

Ontology/Pathway Information

Entrez Gene ID1562
Gene Namecytochrome P450, family 2, subfamily C, polypeptide 18
Gene Symbol CYP2C18
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IBA:GO_CentralCcytoplasm
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0043231 IBA:GO_CentralCintracellular membrane-bounded organelle
GO:0008392 IBA:GO_CentralFarachidonic acid epoxygenase activity
GO:0070330 IEA:UniProtKB-ECFaromatase activity
GO:0020037 IBA:GO_CentralFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0004497 TAS:ProtIncFmonooxygenase activity
GO:0016712 IBA:GO_CentralFoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 TAS:ProtIncFoxygen binding
GO:0008395 IBA:GO_CentralFsteroid hydroxylase activity
GO:0019373 IBA:GO_CentralPepoxygenase P450 pathway
GO:0042738 IBA:GO_CentralPexogenous drug catabolic process
GO:0055114 IBA:GO_CentralPoxidation-reduction process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006805 IBA:GO_CentralPxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_13705Phase 1 - Functionalization of compounds
REACT_13543Xenobiotics
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