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MGP000763

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 4, subfamily A, polypeptide 11
Protein EntryCP4AB_HUMAN
UniProt IDQ02928
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q02928-1; Sequence=Displayed; Name=2; IsoId=Q02928-2; Sequence=VSP_034595;
Catalytic ActivityOctane + 2 reduced rubredoxin + O(2) + 2 H(+) = 1-octanol + 2 oxidized rubredoxin + H(2)O. {ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:7679927}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269|PubMed:11139583};
FunctionCatalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). {ECO:0000269|PubMed:15611369, ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:7679927}.
PolymorphismCYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue SpecificityKidney and liver. {ECO:0000269|PubMed:7679927}.
Web ResourceName=Cytochrome P450 Allele Nomenclature Committee; Note=CYP4A11 alleles; URL="http://www.cypalleles.ki.se/cyp4a11.htm";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cyp4a11/";
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