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MGP000765

Record overview

MGPD IDMGP000765
Gene ID1581
SpeciesHomo sapiens (Human)
Gene Namecytochrome P450, family 7, subfamily A, polypeptide 1
Gene Symbol CYP7A1
SynonymsCP7A; CYP7; CYPVII;
Alternate namescholesterol 7-alpha-monooxygenase; cholesterol 7-alpha-hydroxylase; cytochrome P450 7A1; cytochrome P450, subfamily VIIA polypeptide 1;
Chromosome8
Map Location8q11-q12
EC Number1.14.13.17
SummaryThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]
OrthologsView orthologs and multiple alignments for CYP7A1

Proteins

cholesterol 7-alpha-monooxygenase
Refseq ID:NP_000771
Protein GI:166295200
UniProt ID:P22680
mRNA ID:NM_000780
Length:504
RefSeq Status:
MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKF
HFATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKA
HILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ
MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEI
YPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYK
FKHL
 
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