MGP Database

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MGP000765

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 7, subfamily A, polypeptide 1
Protein EntryCP7A1_HUMAN
UniProt IDP22680
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCholesterol + NADPH + O(2) = 7-alpha- hydroxycholesterol + NADP(+) + H(2)O. {ECO:0000269|PubMed:2384150}.
CofactorName=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000269|Ref.9};
FunctionCatalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. {ECO:0000269|PubMed:19965590}.
InductionUp-regulated by glucose and by cholestyramine. Down- regulated by chenodeoxycholic acid. {ECO:0000269|PubMed:15796896, ECO:0000269|PubMed:19965590}.
PathwayLipid metabolism; bile acid biosynthesis.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue SpecificityDetected in liver. {ECO:0000269|PubMed:15796896}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CYP7A1ID40254ch8q12.html";
Web ResourceName=Wikipedia; Note=Cholesterol-7 alpha-hydroxylase entry; URL="http://en.wikipedia.org/wiki/Cholesterol_7_alpha-hydroxylase";
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