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MGP000771

Record overview

MGPD IDMGP000771
Gene ID1588
SpeciesHomo sapiens (Human)
Gene Namecytochrome P450, family 19, subfamily A, polypeptide 1
Gene Symbol CYP19A1
SynonymsARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM;
Alternate namesaromatase; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, subfamily XIX (aromatization of androgens); estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; microsomal monooxygenase;
Chromosome15
Map Location15q21.1
EC Number1.14.14.14
SummaryThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
OrthologsView orthologs and multiple alignments for CYP19A1

Proteins

aromatase
Refseq ID:NP_000094
Protein GI:13904858
UniProt ID:P11511
mRNA ID:NM_000103
Length:503
RefSeq Status:
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKS
SSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSN
TLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGR
MHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRC
LEH
 
aromatase
Refseq ID:NP_112503
Protein GI:13904860
UniProt ID:P11511
mRNA ID:NM_031226
Length:503
RefSeq Status:
Protein sequence is identical to GI:13904858 (mRNA isoform)
 
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