MGP Database

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MGP000771

Ontology/Pathway Information

Entrez Gene ID1588
Gene Namecytochrome P450, family 19, subfamily A, polypeptide 1
Gene Symbol CYP19A1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005783 IDA:LIFEdbCendoplasmic reticulum
GO:0005789 TAS:ReactomeCendoplasmic reticulum membrane
GO:0016020 TAS:ProtIncCmembrane
GO:0070330 IDA:UniProtKBFaromatase activity
GO:0009055 TAS:UniProtKBFelectron carrier activity
GO:0020037 IDA:UniProtKBFheme binding
GO:0005506 IEA:InterProFiron ion binding
GO:0016712 TAS:UniProtKBFoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825 TAS:ProtIncFoxygen binding
GO:0008209 IEA:EnsemblPandrogen metabolic process
GO:0006703 TAS:ReactomePestrogen biosynthetic process
GO:0060736 IEA:EnsemblPprostate gland growth
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006694 TAS:ProtIncPsteroid biosynthetic process
GO:0008202 TAS:ReactomePsteroid metabolic process
GO:0016125 TAS:ReactomePsterol metabolic process
GO:0006805 TAS:ReactomePxenobiotic metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13433Biological oxidations
REACT_13567Cytochrome P450 - arranged by substrate type
REACT_268767Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
REACT_268601Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REACT_268761Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
REACT_268217Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
REACT_268478Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
REACT_268087Defective CYP1B1 causes Glaucoma
REACT_267893Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
REACT_268803Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
REACT_268108Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
REACT_267734Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
REACT_268413Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
REACT_268633Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
REACT_268491Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
REACT_268326Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
REACT_268441Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
REACT_267709Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
REACT_268486Defective FMO3 causes Trimethylaminuria (TMAU)
REACT_267863Defective MAOA causes Brunner syndrome (BRUNS)
REACT_268528Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
REACT_116125Disease
REACT_13812Endogenous sterols
REACT_11037Estrogen biosynthesis
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_11057Metabolism of steroid hormones and vitamin D
REACT_13705Phase 1 - Functionalization of compounds
SMP Pathway Links
SMP IDDescription
SMP0035617-Beta Hydroxysteroid Dehydrogenase III Deficiency
SMP00068Androgen and Estrogen Metabolism
SMP00565Aromatase deficiency
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