MGP Database

MGP000780

Record overview

MGPD ID	MGP000780
Gene ID	1604
Species	Homo sapiens (Human)
Gene Name	CD55 molecule, decay accelerating factor for complement (Cromer blood group)
Gene Symbol	CD55
Synonyms	CR; TC; DAF; CROM;
Alternate names	complement decay-accelerating factor; CD55 antigen;
Chromosome	1
Map Location	1q32
Summary	This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]
Orthologs	View orthologs and multiple alignments for CD55

Proteins

complement decay-accelerating factor isoform 1 preproprotein

Refseq ID:	NP_000565
Protein GI:	10835143
UniProt ID:	P08174
mRNA ID:	NM_000574
Length:	381
RefSeq Status:

`MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEV PTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGST SSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT TVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLSGHTCFTLTGLLGTLVTMGLLT`

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

mat_peptide: 35..353
product: Complement decay-accelerating factor
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P08174.4)
calculated_mol_wt: 34964
peptide sequence: 
DCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR
REPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNG
IIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVS
RTTKHFHETTPNKGSGTTS

complement decay-accelerating factor isoform 2 precursor

Refseq ID:	NP_001108224
Protein GI:	168693643
UniProt ID:	P08174
mRNA ID:	NM_001114752
Length:	440
RefSeq Status:

MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEV
PTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGST
SSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT
TVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLSGSRPVTQAGMRWCDRSSLQSRTPGFKRSFHFSLPSSWYYR
AHVFHVDRFAWDASNHGLADLAKEELRRKYTQVYRLFLVS

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

mat_peptide: 35..353
product: Complement decay-accelerating factor
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P08174.4)
calculated_mol_wt: 34964
peptide sequence: 
DCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR
REPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNG
IIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVS
RTTKHFHETTPNKGSGTTS

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

complement decay-accelerating factor isoform 5 precursor

Refseq ID:	NP_001287831
Protein GI:	665505989
UniProt ID:	B1AP13
mRNA ID:	NM_001300902
Length:	444
RefSeq Status:

MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEV
PTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGST
SSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT
TVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLSGSRPVTQAGMRWCDRSSLQSRTPGFKRSFHFSLPSSWYYR
CVPRHPAKFLKFIFCRDRIFLCCPGWFQTPGRKRFFRPPKTLRL

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

mat_peptide: 35..353
product: Complement decay-accelerating factor
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P08174.4)
calculated_mol_wt: 34964
peptide sequence: 
DCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR
REPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNG
IIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVS
RTTKHFHETTPNKGSGTTS

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

complement decay-accelerating factor isoform 6 precursor

Refseq ID:	NP_001287832
Protein GI:	665505991
UniProt ID:	P08174
mRNA ID:	NM_001300903
Length:	439
RefSeq Status:

MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEV
PTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGST
SSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT
TVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLSETVFHRVIQDGLDLLASRSACLGLPKCWDYRREPPHLARA
HVFHVDRFAWDASNHGLADLAKEELRRKYTQVYRLFLVS

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

mat_peptide: 35..353
product: Complement decay-accelerating factor
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P08174.4)
calculated_mol_wt: 34964
peptide sequence: 
DCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR
REPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNG
IIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVS
RTTKHFHETTPNKGSGTTS

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

complement decay-accelerating factor isoform 7 precursor

Refseq ID:	NP_001287833
Protein GI:	665505993
UniProt ID:	P08174
mRNA ID:	NM_001300904
Length:	384
RefSeq Status:

`MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEV PTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGST SSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPT TVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLSALQVRPFEVSGSSHISSKKMMCIL`

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG

mat_peptide: 35..353
product: Complement decay-accelerating factor
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P08174.4)
calculated_mol_wt: 34964
peptide sequence: 
DCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYR
REPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNG
IIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVS
RTTKHFHETTPNKGSGTTS

sig_peptide: 1..34
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3594
peptide sequence: 
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWG