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MGP000780

UniProt Annotations

Entry Information
Gene NameCD55 molecule, decay accelerating factor for complement (Cromer blood group)
Protein EntryDAF_HUMAN
UniProt IDP08174
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=7; Name=2; Synonyms=DAF-2; IsoId=P08174-1; Sequence=Displayed; Name=1; Synonyms=DAF-1; IsoId=P08174-2; Sequence=VSP_001200; Name=3; Synonyms=VDAF3; IsoId=P08174-3; Sequence=VSP_047636; Name=4; Synonyms=VDAF2; IsoId=P08174-4; Sequence=VSP_047637; Name=5; Synonyms=VDAF1; IsoId=P08174-5; Sequence=VSP_047638; Name=6; Synonyms=VDAF4; IsoId=P08174-6; Sequence=VSP_047635; Note=Includes partial sequence of the intron 7.; Name=7; Synonyms=VDAF5; IsoId=P08174-7; Sequence=VSP_047634; Note=Includes full sequence of the intron 7.;
DomainThe first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity). {ECO:0000250}.
FunctionThis protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. {ECO:0000269|PubMed:7525274}.
PolymorphismResponsible for the Cromer blood group system (CROM) [MIM:613793]. It consists of at least 8 high-incidence (Cr(a), Tc(a), Dr(a), Es(a), WES(b), UMC, IFC and GUTI) and three low- incidence (Tc(b), Tc(c) and WES(a)) antigens that reside on DAF. In the Cromer phenotypes Dr(a-) and Inab there is reduced or absent expression of DAF, respectively. In the case of the Dr(a-) phenotype, a single nucleotide substitution within exon 5 accounts for two changes: a simple amino acid substitution, Leu-199 that is the basis of the antigenic variation, and an alternative splicing event that underlies the decreased expression of DAF in this phenotype. The Inab phenotype is a very rare one in which the red blood cells lack all Cromer system antigens. The red blood cells of individuals with Inab phenotype have a deficiency of DAF, but these individuals are not known to have any associated hematologic or other abnormalities.
PtmThe Ser/Thr-rich domain is heavily O-glycosylated. {ECO:0000269|PubMed:19159218}.
SimilarityBelongs to the receptors of complement activation (RCA) family. {ECO:0000305}.
SimilarityContains 4 Sushi (CCP/SCR) domains. {ECO:0000255|PROSITE-ProRule:PRU00302}.
Subcellular LocationIsoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular LocationIsoform 2: Cell membrane; Lipid-anchor, GPI- anchor.
Subcellular LocationIsoform 3: Secreted {ECO:0000269|PubMed:16503113}.
Subcellular LocationIsoform 4: Secreted {ECO:0000269|PubMed:16503113}.
Subcellular LocationIsoform 5: Secreted {ECO:0000269|PubMed:16503113}.
Subcellular LocationIsoform 6: Cell membrane {ECO:0000305|PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:16503113}.
Subcellular LocationIsoform 7: Cell membrane {ECO:0000305|PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:16503113}.
SubunitMonomer (major form) and non-disulfide-linked, covalent homodimer (minor form). Binds to coxsackievirus A21, coxsackieviruses B1, B3 and B5, human enterovirus 70, human echoviruses 6, 7, 11, 12, 20 and 21 capsid proteins and acts as a receptor for these viruses. {ECO:0000269|PubMed:1377029}.
Tissue SpecificityExpressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.
Web ResourceName=CD55base; Note=CD55 mutation db; URL="http://structure.bmc.lu.se/idbase/CD55base/";
Web ResourceName=dbRBC/BGMUT; Note=Blood group antigen gene mutation database; URL="http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=cromer";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/daf/";
Web ResourceName=Virus Particle ExploreR db; Note=Icosahedral capsid structure; URL="http://viperdb.scripps.edu/info_page.php?VDB=1upn";
Web ResourceName=Wikipedia; Note=Decay-accelerating factor entry; URL="http://en.wikipedia.org/wiki/Decay_accelerating_factor";
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