MGP Database

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MGP000782

UniProt Annotations

Entry Information
Gene Namediacylglycerol kinase, alpha 80kDa
Protein EntryDGKA_HUMAN
UniProt IDP23743
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P23743-1; Sequence=Displayed; Name=2; IsoId=P23743-2; Sequence=VSP_032212, VSP_032213; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=P23743-3; Sequence=VSP_047702, VSP_047703;
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme RegulationStimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C.
FunctionUpon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.
SimilarityBelongs to the eukaryotic diacylglycerol kinase family. {ECO:0000305}.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
SimilarityContains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
SimilarityContains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00226}.
SubunitMonomer.
Tissue SpecificityLymphocytes and oligodendroglial cells.
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