MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000795

Record overview

MGPD IDMGP000795
Gene ID1633
SpeciesHomo sapiens (Human)
Gene Namedeoxycytidine kinase
Gene Symbol DCK
Alternate namesdeoxycytidine kinase; deoxynucleoside kinase;
Chromosome4
Map Location4q13.3-q21.1
EC Number2.7.1.74;
Summary Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DCK

Proteins

deoxycytidine kinase
Refseq ID:NP_000779
Protein GI:4503269
UniProt ID:P27707
mRNA ID:NM_000788
Length:260
RefSeq Status:
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYA
CLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGI
PLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
 
  logo