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MGP000795

UniProt Annotations

Entry Information
Gene Namedeoxycytidine kinase
Protein EntryDCK_HUMAN
UniProt IDP27707
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=6.2 uM for deoxycytidine (dC) {ECO:0000269|PubMed:12808445}; KM=15.5 uM for cytarabine (araC) {ECO:0000269|PubMed:12808445}; KM=22 uM for gemcitabine (dC) {ECO:0000269|PubMed:12808445};
Catalytic ActivityNTP + deoxycytidine = NDP + dCMP. {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:19159229, ECO:0000269|PubMed:20614893}.
CautionWas shown to be phosphorylated and activated by CSNK1D/CK1 in vitro but probably not in vivo. {ECO:0000305|PubMed:20637175}.
FunctionRequired for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. {ECO:0000269|PubMed:18377927, ECO:0000269|PubMed:20614893}.
PtmPhosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1. {ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:20637175}.
SimilarityBelongs to the DCK/DGK family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:9342341}.
SubunitHomodimer. {ECO:0000269|PubMed:12808445, ECO:0000269|PubMed:16421443, ECO:0000269|PubMed:19836232, ECO:0000269|PubMed:20614893, ECO:0000269|PubMed:20684612}.
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