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MGP000797

Record overview

MGPD IDMGP000797
Gene ID1635
SpeciesHomo sapiens (Human)
Gene NamedCMP deaminase
Gene Symbol DCTD
Alternate namesdeoxycytidylate deaminase;
Chromosome4
Map Location4q35.1
EC Number3.5.4.12
SummaryThe protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DCTD

Proteins

deoxycytidylate deaminase isoform a
Refseq ID:NP_001012750
Protein GI:61742821
UniProt ID:P32321
mRNA ID:NM_001012732
Length:189
RefSeq Status:
MVGGGQPCGPNMSEVSCKKRDDYLEWPEYFMAVAFLSAQRSKDPNSQVGACIVNSENKIVGIGYNGMPNGCSDDVLPWRRTAENKLDTKYPYVCHAELNA
IMNKNSTDVKGCSMYVALFPCNECAKLIIQAGIKEVIFMSDKYHDSDEATAARLLFNMAGVTFRKFIPKCSKIVIDFDSINSRPSQKLQ
 
deoxycytidylate deaminase isoform b
Refseq ID:NP_001912
Protein GI:61742819
UniProt ID:P32321
mRNA ID:NM_001921
Length:178
RefSeq Status:
MSEVSCKKRDDYLEWPEYFMAVAFLSAQRSKDPNSQVGACIVNSENKIVGIGYNGMPNGCSDDVLPWRRTAENKLDTKYPYVCHAELNAIMNKNSTDVKG
CSMYVALFPCNECAKLIIQAGIKEVIFMSDKYHDSDEATAARLLFNMAGVTFRKFIPKCSKIVIDFDSINSRPSQKLQ
 
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