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MGP000807

Record overview

MGPD IDMGP000807
Gene ID1649
SpeciesHomo sapiens (Human)
Gene NameDNA-damage-inducible transcript 3
Gene Symbol DDIT3
SynonymsCHOP; CEBPZ; CHOP10; CHOP-10; GADD153;
Alternate namesDNA damage-inducible transcript 3 protein; DDIT-3; C/EBP zeta; c/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; growth arrest and DNA damage-inducible protein GADD153;
Chromosome12
Map Location12q13.1-q13.2
SummaryThis gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]
OrthologsView orthologs and multiple alignments for DDIT3

Proteins

DNA damage-inducible transcript 3 protein isoform 1
Refseq ID:NP_001181982
Protein GI:304282225
UniProt ID:P35638
mRNA ID:NM_001195053
Length:192
RefSeq Status:
MELVPATPHYPADVLFQTDPTAEMAAESLPFSFGTLSSWELEAWYEDLQEVLSSDENGGTYVSPPGNEEEESKIFTTLDPASLAWLTEEEPEPAEVTSTS
QSPHSPDSSQSSLAQEEEEEDQGRTRKRKQSGHSPARAGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRRALIDRMVNLHQA
 
DNA damage-inducible transcript 3 protein isoform 1
Refseq ID:NP_001181984
Protein GI:304282229
UniProt ID:P35638
mRNA ID:NM_001195055
Length:192
RefSeq Status:
Protein sequence is identical to GI:304282225 (mRNA isoform)
 
DNA damage-inducible transcript 3 protein isoform 1
Refseq ID:NP_001181983
Protein GI:304282227
UniProt ID:P35638
mRNA ID:NM_001195054
Length:192
RefSeq Status:
Protein sequence is identical to GI:304282225 (mRNA isoform)
 
DNA damage-inducible transcript 3 protein isoform 1
Refseq ID:NP_001181985
Protein GI:304282231
UniProt ID:Q53YD1
mRNA ID:NM_001195056
Length:192
RefSeq Status:
Protein sequence is identical to GI:304282225 (mRNA isoform)
 
DNA damage-inducible transcript 3 protein isoform 2
Refseq ID:NP_004074
Protein GI:21361118
UniProt ID:P35638
mRNA ID:NM_004083
Length:169
RefSeq Status:
MAAESLPFSFGTLSSWELEAWYEDLQEVLSSDENGGTYVSPPGNEEEESKIFTTLDPASLAWLTEEEPEPAEVTSTSQSPHSPDSSQSSLAQEEEEEDQG
RTRKRKQSGHSPARAGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVEATRRALIDRMVNLHQA
 
DNA damage-inducible transcript 3 protein isoform 2
Refseq ID:NP_001181986
Protein GI:304282234
UniProt ID:P35638
mRNA ID:NM_001195057
Length:169
RefSeq Status:
Protein sequence is identical to GI:21361118 (mRNA isoform)
 
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