MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000807

Ontology/Pathway Information

Entrez Gene ID1649
Gene NameDNA-damage-inducible transcript 3
Gene Symbol DDIT3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ParkinsonsUK-UCLCcytosol
GO:0005770 IEA:EnsemblClate endosome
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0003677 IDA:UniProtKBFDNA binding
GO:0046982 TAS:ParkinsonsUK-UCLFprotein heterodimerization activity
GO:0043565 IEA:InterProFsequence-specific DNA binding
GO:0003700 NAS:ProtIncFsequence-specific DNA binding transcription factor activity
GO:0003714 TAS:ProtIncFtranscription corepressor activity
GO:0008134 IPI:BHF-UCLFtranscription factor binding
GO:0044212 ISS:ParkinsonsUK-UCLFtranscription regulatory region DNA binding
GO:0006987 TAS:ReactomePactivation of signaling protein activity involved in unfolded protein response
GO:0001955 IEA:EnsemblPblood vessel maturation
GO:0007050 IEA:UniProtKB-KWPcell cycle arrest
GO:0045454 IDA:MGIPcell redox homeostasis
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0006974 TAS:ProtIncPcellular response to DNA damage stimulus
GO:0030968 TAS:ReactomePendoplasmic reticulum unfolded protein response
GO:0006983 IEA:EnsemblPER overload response
GO:0070059 IDA:UniProtKBPintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0042789 IDA:MGIPmRNA transcription from RNA polymerase II promoter
GO:0090090 ISS:BHF-UCLPnegative regulation of canonical Wnt signaling pathway
GO:2000016 IDA:BHF-UCLPnegative regulation of determination of dorsal identity
GO:0045662 IEA:EnsemblPnegative regulation of myoblast differentiation
GO:0043433 IDA:BHF-UCLPnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0032757 IMP:UniProtKBPpositive regulation of interleukin-8 production
GO:0043525 IEA:EnsemblPpositive regulation of neuron apoptotic process
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IMP:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:1990440 ISS:ParkinsonsUK-UCLPpositive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0043161 IDA:UniProtKBPproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043620 TAS:BHF-UCLPregulation of DNA-templated transcription in response to stress
GO:0006355 IMP:UniProtKBPregulation of transcription, DNA-templated
GO:0044324 ISS:BHF-UCLPregulation of transcription involved in anterior/posterior axis specification
GO:0051209 IEA:EnsemblPrelease of sequestered calcium ion into cytosol
GO:0034976 IDA:UniProtKBPresponse to endoplasmic reticulum stress
GO:0042594 IEA:EnsemblPresponse to starvation
GO:0006986 IDA:UniProtKBPresponse to unfolded protein
GO:0016055 IEA:UniProtKB-KWPWnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18355ATF4 activates genes
REACT_18423ATF6-alpha activates chaperone genes
REACT_18348ATF6-alpha activates chaperones
REACT_17015Metabolism of proteins
REACT_18277PERK regulates gene expression
REACT_18356Unfolded Protein Response (UPR)
  logo