MGP Database

MGP000815

Record overview

MGPD ID	MGP000815
Gene ID	1669
Species	Homo sapiens (Human)
Gene Name	defensin, alpha 4, corticostatin
Gene Symbol	DEFA4
Synonyms	HP4; DEF4; HP-4; HNP-4;
Alternate names	neutrophil defensin 4; corticostatin; defensin, alpha 4, preproprotein;
Chromosome	8
Map Location	8p23
Summary	Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014]
Orthologs	View orthologs and multiple alignments for DEFA4

Proteins

neutrophil defensin 4 preproprotein

Refseq ID:	NP_001916
Protein GI:	4503303
UniProt ID:	P12838
mRNA ID:	NM_001925
Length:	97
RefSeq Status:

`MRIIALLAAILLVALQVRAGPLQARGDEAPGQEQRGPEDQDISISFAWDKSSALQVSGSTRGMVCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD`

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2049
peptide sequence: 
MRIIALLAAILLVALQVRA

mat_peptide: 64..96
product: neutrophil defensin 4
experiment: DESCRIPTION:antimicrobial peptide[PMID: 2500436]
calculated_mol_wt: 3715
peptide sequence: 
VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV