MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000815

UniProt Annotations

Entry Information
Gene Namedefensin, alpha 4, corticostatin
Protein EntryDEF4_HUMAN
UniProt IDP12838
SpeciesHuman
Comments
Comment typeDescription
FunctionHas antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production. {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:15620707}.
SimilarityBelongs to the alpha-defensin family. {ECO:0000305}.
Subcellular LocationSecreted.
SubunitHomodimer. {ECO:0000269|PubMed:17088326}.
  logo