MGP Database

MGP000816

Record overview

MGPD ID	MGP000816
Gene ID	1670
Species	Homo sapiens (Human)
Gene Name	defensin, alpha 5, Paneth cell-specific
Gene Symbol	DEFA5
Synonyms	DEF5; HD-5;
Alternate names	defensin-5; HD5(20-94); defensin 5; defensin, alpha 5, preproprotein;
Chromosome	8
Map Location	8p23.1
Summary	Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]
Orthologs	View orthologs and multiple alignments for DEFA5

Proteins

defensin-5 preproprotein

Refseq ID:	NP_066290
Protein GI:	10337585
UniProt ID:	Q01523
mRNA ID:	NM_021010
Length:	94
RefSeq Status:

`MRTIAILAAILLVALQAQAESLQERADEATTQKQSGEDNQDLAISFAGNGLSALRTSGSQARATCYCRTGRCATRESLSGVCEISGRLYRLCCR`

sig_peptide: 1..19
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1980
peptide sequence: 
MRTIAILAAILLVALQAQA

mat_peptide: 63..94
product: defensin-5
experiment: DESCRIPTION:antimicrobial peptide[PMID: 15616305]
calculated_mol_wt: 3588
peptide sequence: 
ATCYCRTGRCATRESLSGVCEISGRLYRLCCR