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MGP000816

UniProt Annotations

Entry Information
Gene Namedefensin, alpha 5, Paneth cell-specific
Protein EntryDEF5_HUMAN
UniProt IDQ01523
SpeciesHuman
Comments
Comment typeDescription
FunctionHas antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:17088326}.
PtmGlycosylated. {ECO:0000269|PubMed:12021776}.
SimilarityBelongs to the alpha-defensin family. {ECO:0000305}.
Subcellular LocationSecreted {ECO:0000269|PubMed:12021776}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:12021776}. Note=Peptides HD5(20-94), HD5(23- 94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form.
SubunitHomodimer. {ECO:0000269|PubMed:17088326}.
Tissue SpecificityPaneth cells of the small intestine (at protein level). {ECO:0000269|PubMed:12021776}.
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