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MGP000828

Record overview

MGPD IDMGP000828
Gene ID1719
SpeciesHomo sapiens (Human)
Gene Namedihydrofolate reductase
Gene Symbol DHFR
SynonymsDYR; DHFRP1;
Alternate namesdihydrofolate reductase;
Chromosome5
Map Location5q11.2-q13.2
EC Number1.5.1.3;
SummaryDihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
OrthologsView orthologs and multiple alignments for DHFR

Proteins

dihydrofolate reductase isoform 1
Refseq ID:NP_000782
Protein GI:4503323
UniProt ID:P00374
mRNA ID:NM_000791
Length:187
RefSeq Status:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKL
TEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
 
dihydrofolate reductase isoform 2
Refseq ID:NP_001277283
Protein GI:594140703
UniProt ID:P00374
mRNA ID:NM_001290354
Length:135
RefSeq Status:
MGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEI
DLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
 
dihydrofolate reductase isoform 3
Refseq ID:NP_001277286
Protein GI:594140705
UniProt ID:B4DM58
mRNA ID:NM_001290357
Length:129
RefSeq Status:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKL
TEQPELANKVDMVWIVGGSSVYKIPRCSL
 
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