MGP Database

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MGP000828

Ontology/Pathway Information

Entrez Gene ID1719
Gene Namedihydrofolate reductase
Gene Symbol DHFR
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0004146 IDA:UniProtKBFdihydrofolate reductase activity
GO:0008144 IDA:UniProtKBFdrug binding
GO:0003729 IDA:UniProtKBFmRNA binding
GO:0050661 IEA:InterProFNADP binding
GO:0046655 TAS:ReactomePfolic acid metabolic process
GO:0000082 TAS:ReactomePG1/S transition of mitotic cell cycle
GO:0006545 IEA:InterProPglycine biosynthetic process
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0046209 TAS:ReactomePnitric oxide metabolic process
GO:0009165 IEA:InterProPnucleotide biosynthetic process
GO:0006730 IEA:UniProtKB-KWPone-carbon metabolic process
GO:0050999 TAS:ReactomePregulation of nitric-oxide synthase activity
GO:0000083 TAS:ReactomePregulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0031427 IEA:UniProtKB-KWPresponse to methotrexate
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0046654 IEA:UniProtKB-UniPathwayPtetrahydrofolate biosynthetic process
GO:0046653 IDA:UniProtKBPtetrahydrofolate metabolic process
GO:0006766 TAS:ReactomePvitamin metabolic process
GO:0006767 TAS:ReactomePwater-soluble vitamin metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403Defective BTD causes biotidinase deficiency
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238Defects in biotin (Btn) metabolism
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169385Defects in vitamin and cofactor metabolism
REACT_116125Disease
REACT_471E2F mediated regulation of DNA replication
REACT_12389eNOS activation and regulation
REACT_683G1/S-Specific Transcription
REACT_1783G1/S Transition
REACT_111217Metabolism
REACT_11167Metabolism of folate and pterines
REACT_12508Metabolism of nitric oxide
REACT_11193Metabolism of vitamins and cofactors
REACT_11238Metabolism of water-soluble vitamins and cofactors
REACT_21267Mitotic G1-G1/S phases
REACT_111176Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
SMP Pathway Links
SMP IDDescription
SMP00486Dopa-responsive dystonia
SMP00724Folate malabsorption, hereditary
SMP00053Folate Metabolism
SMP00543Homocystinuria due to defect of N(5,10)-methylene THF deficiency
SMP00487Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency
SMP00488Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps)
SMP00489Hyperphenylalaninemia due to dhpr-deficiency
SMP00432Methotrexate Action Pathway
SMP00005Pterine Biosynthesis
SMP00490Segawa syndrome
SMP00491Sepiapterin reductase deficiency
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