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MGP000829

Record overview

MGPD IDMGP000829
Gene ID1723
SpeciesHomo sapiens (Human)
Gene Namedihydroorotate dehydrogenase (quinone)
Gene Symbol DHODH
SynonymsURA1; POADS; DHOdehase;
Alternate namesdihydroorotate dehydrogenase (quinone), mitochondrial; dihydroorotate oxidase; human complement of yeast URA1;
Chromosome16
Map Location16q22
EC Number1.3.5.2
SummaryThe protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for DHODH

Proteins

dihydroorotate dehydrogenase (quinone), mitochondrial
Refseq ID:NP_001352
Protein GI:45006951
UniProt ID:Q02127
mRNA ID:NM_001361
Length:395
RefSeq Status:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKH
GEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRV
LGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
 
transit_peptide: 1..10
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion, not cleaved (By similarity); propagated from UniProtKB/Swiss-Prot (Q02127.3)
calculated_mol_wt: 1297
peptide sequence: 
MAWRHLKKRA
 
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