MGP Database

MGP000829

Ontology/Pathway Information

Entrez Gene ID	1723
Gene Name	dihydroorotate dehydrogenase (quinone)
Gene Symbol	DHODH
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0031304	IBA:GO_Central	C	intrinsic component of mitochondrial inner membrane
GO:0005743	TAS:Reactome	C	mitochondrial inner membrane
GO:0005739	IDA:HPA	C	mitochondrion
GO:0043025	IEA:Ensembl	C	neuronal cell body
GO:0005654	IDA:HPA	C	nucleoplasm
GO:0004152	IBA:GO_Central	F	dihydroorotate dehydrogenase activity
GO:0008144	IEA:Ensembl	F	drug binding
GO:0010181	IEA:Ensembl	F	FMN binding
GO:0048039	IEA:Ensembl	F	ubiquinone binding
GO:0006207	IBA:GO_Central	P	'de novo' pyrimidine nucleobase biosynthetic process
GO:0044205	IEA:UniProtKB-UniPathway	P	'de novo' UMP biosynthetic process
GO:0007565	IEA:Ensembl	P	female pregnancy
GO:0007595	IEA:Ensembl	P	lactation
GO:0055086	TAS:Reactome	P	nucleobase-containing small molecule metabolic process
GO:0043065	IEA:Ensembl	P	positive regulation of apoptotic process
GO:0006206	TAS:Reactome	P	pyrimidine nucleobase metabolic process
GO:0046134	TAS:Reactome	P	pyrimidine nucleoside biosynthetic process
GO:0090140	IEA:Ensembl	P	regulation of mitochondrial fission
GO:0031000	IEA:Ensembl	P	response to caffeine
GO:0042493	IEA:Ensembl	P	response to drug
GO:0042594	IEA:Ensembl	P	response to starvation
GO:0044281	TAS:Reactome	P	small molecule metabolic process

REACTOME Pathway Links

SMP Pathway Links

SMP ID	Description
SMP00172	Beta Ureidopropionase Deficiency
SMP00178	Dihydropyrimidinase Deficiency
SMP00202	MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
SMP00046	Pyrimidine Metabolism
SMP00219	UMP Synthase Deiciency (Orotic Aciduria)