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MGP000832

Record overview

MGPD IDMGP000832
Gene ID1728
SpeciesHomo sapiens (Human)
Gene NameNAD(P)H dehydrogenase, quinone 1
Gene Symbol NQO1
SynonymsDTD; QR1; DHQU; DIA4; NMOR1; NMORI;
Alternate namesNAD(P)H dehydrogenase [quinone] 1; DT-diaphorase; NAD(P)H:Quinone acceptor oxidoreductase type 1; NAD(P)H:menadione oxidoreductase 1; NAD(P)H:quinone oxidoreductase 1; NAD(P)H:quinone oxireductase; azoreductase; diaphorase (NADH/NADPH) (cytochrome b-5 reductase); diaphorase-4; dioxin-inducible 1; menadione reductase; phylloquinone reductase; quinone reductase 1;
Chromosome16
Map Location16q22.1
EC Number1.6.5.2
SummaryThis gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for NQO1

Proteins

NAD(P)H dehydrogenase [quinone] 1 isoform a
Refseq ID:NP_000894
Protein GI:4505415
UniProt ID:P15559
mRNA ID:NM_000903
Length:274
RefSeq Status:
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIF
QFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADA
RIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
 
NAD(P)H dehydrogenase [quinone] 1 isoform b
Refseq ID:NP_001020604
Protein GI:70995396
UniProt ID:P15559
mRNA ID:NM_001025433
Length:240
RefSeq Status:
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIF
QFPLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQ
AGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
 
NAD(P)H dehydrogenase [quinone] 1 isoform c
Refseq ID:NP_001020605
Protein GI:70995422
UniProt ID:P15559
mRNA ID:NM_001025434
Length:236
RefSeq Status:
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIF
QSKKAVLSITTGGSGSMYSLQGIHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFL
MKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK
 
NAD(P)H dehydrogenase [quinone] 1 isoform d
Refseq ID:NP_001273066
Protein GI:554790420
UniProt ID:B4DLR8
mRNA ID:NM_001286137
Length:202
RefSeq Status:
MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYAMNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIF
QSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDETPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKA
RK
 
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