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MGP000832

UniProt Annotations

Entry Information
Gene NameNAD(P)H dehydrogenase, quinone 1
Protein EntryNQO1_HUMAN
UniProt IDP15559
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P15559-1; Sequence=Displayed; Name=2; IsoId=P15559-2; Sequence=VSP_042716; Note=No experimental confirmation available.; Name=3; IsoId=P15559-3; Sequence=VSP_044446; Note=No experimental confirmation available.;
Catalytic ActivityNAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692;
Enzyme RegulationInhibited by dicoumarol.
FunctionThe enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
InductionBy dioxin.
InteractionSelf; NbExp=5; IntAct=EBI-3989435, EBI-3989435; Q9UK53:ING1; NbExp=3; IntAct=EBI-3989435, EBI-399198; O88898-2:Tp63 (xeno); NbExp=2; IntAct=EBI-3989435, EBI-2338228; O88898-6:Tp63 (xeno); NbExp=2; IntAct=EBI-3989435, EBI-2338244;
Mass SpectrometryMass=30864; Mass_error=6; Method=Electrospray; Range=2-274; Evidence={ECO:0000269|PubMed:11735396};
MiscellaneousQuinone reductase accepts electrons from both NADH and NADPH with equal efficiency.
PolymorphismThe Ser-187 polymorphism may be linked to susceptibility to forms of cancers.
SimilarityBelongs to the NAD(P)H dehydrogenase (quinone) family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer. {ECO:0000269|PubMed:10543876, ECO:0000269|PubMed:10706635, ECO:0000269|PubMed:11587640, ECO:0000269|PubMed:11735396, ECO:0000269|PubMed:16700548}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/NQO1ID375.html";
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/nqo1/";
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