MGP Database

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MGP000863

UniProt Annotations

Entry Information
Gene NameDPH2 homolog (S. cerevisiae)
Protein EntryDPH2_HUMAN
UniProt IDQ9BQC3
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BQC3-1; Sequence=Displayed; Name=2; IsoId=Q9BQC3-2; Sequence=VSP_047151; Note=Gene prediction based on EST data.; Name=3; IsoId=Q9BQC3-3; Sequence=VSP_056052, VSP_056053; Note=No experimental confirmation available.;
FunctionRequired for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). {ECO:0000250}.
PathwayProtein modification; peptidyl-diphthamide biosynthesis.
SimilarityBelongs to the DPH1/DPH2 family. DPH2 subfamily. {ECO:0000305}.
SubunitInteracts with DPH1. {ECO:0000250}.
Tissue SpecificityStrongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver, pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, spleen, thymus, prostate, ovary and lymphocytes. {ECO:0000269|PubMed:9782084}.
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