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MGP000887

UniProt Annotations

Entry Information
Gene Namedual specificity phosphatase 3
Protein EntryDUS3_HUMAN
UniProt IDP51452
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P51452-1; Sequence=Displayed; Name=2; IsoId=P51452-2; Sequence=VSP_056284; Note=No experimental confirmation available.;
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Catalytic ActivityProtein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10044}.
FunctionShows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:11863439}.
SimilarityBelongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. {ECO:0000305}.
SimilarityContains 1 tyrosine-protein phosphatase domain. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:10224087}.
SubunitInteracts with VRK3, which seems to activate it's phosphatase activity. {ECO:0000250}.
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