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MGP000890

UniProt Annotations

Entry Information
Gene Namedual specificity phosphatase 7
Protein EntryDUS7_HUMAN
UniProt IDQ16829
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative promoter usage; Named isoforms=2; Name=1; Synonyms=PYST2-L; IsoId=Q16829-1; Sequence=Displayed; Name=2; Synonyms=PYST2-S; IsoId=Q16829-2; Sequence=VSP_012822;
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Catalytic ActivityProtein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CautionAn out-of-frame translation product, PYST2SB, has been experimentally demonstrated to be formed from the alternative promoter. The expression of the in-frame product has not yet been shown. {ECO:0000305}.
FunctionRegulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors. {ECO:0000269|PubMed:14603440}.
InteractionP10912:GHR; NbExp=2; IntAct=EBI-1265847, EBI-286316; O43791:SPOP; NbExp=5; IntAct=EBI-1265847, EBI-743549;
SimilarityBelongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. {ECO:0000305}.
SimilarityContains 1 rhodanese domain. {ECO:0000255|PROSITE- ProRule:PRU00173}.
SimilarityContains 1 tyrosine-protein phosphatase domain. {ECO:0000305}.
Subcellular LocationCytoplasm.
Tissue SpecificityExpressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells. {ECO:0000269|PubMed:14576828}.
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