MGP Database

MGP000906

Record overview

MGPD ID	MGP000906
Gene ID	1906
Species	Homo sapiens (Human)
Gene Name	endothelin 1
Gene Symbol	EDN1
Synonyms	ET1; QME; PPET1; ARCND3; HDLCQ7;
Alternate names	endothelin-1; preproendothelin-1;
Chromosome	6
Map Location	6p24.1
Summary	The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Orthologs	View orthologs and multiple alignments for EDN1

Proteins

endothelin-1 isoform 1 preproprotein

Refseq ID:	NP_001946
Protein GI:	154800437
UniProt ID:	P05305
mRNA ID:	NM_001955
Length:	212
RefSeq Status:

`MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPT KATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPS RERYVTHNRAHW`

sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1964
peptide sequence: 
MDYLLMIFSLLFVACQG

mat_peptide: 52..72
product: endothelin-1 isoform 2
calculated_mol_wt: 2496
peptide sequence: 
CSCSSLMDKECVYFCHLDIIW

sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1964
peptide sequence: 
MDYLLMIFSLLFVACQG

mat_peptide: 53..73
product: endothelin-1 isoform 1
calculated_mol_wt: 2496
peptide sequence: 
CSCSSLMDKECVYFCHLDIIW

endothelin-1 isoform 2 preproprotein

Refseq ID:	NP_001161791
Protein GI:	269995983
UniProt ID:	P05305
mRNA ID:	NM_001168319
Length:	211
RefSeq Status:

`MDYLLMIFSLLFVACQGAPETVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTK ATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSR ERYVTHNRAHW`

sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1964
peptide sequence: 
MDYLLMIFSLLFVACQG

mat_peptide: 52..72
product: endothelin-1 isoform 2
calculated_mol_wt: 2496
peptide sequence: 
CSCSSLMDKECVYFCHLDIIW