MGP Database

MGP000906

Ontology/Pathway Information

Entrez Gene ID	1906
Gene Name	endothelin 1
Gene Symbol	EDN1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0045178	IEA:Ensembl	C	basal part of cell
GO:0005737	IDA:BHF-UCL	C	cytoplasm
GO:0005576	TAS:Reactome	C	extracellular region
GO:0005615	IDA:BHF-UCL	C	extracellular space
GO:0048237	IEA:Ensembl	C	rough endoplasmic reticulum lumen
GO:0033093	IEA:Ensembl	C	Weibel-Palade body
GO:0005125	IDA:BHF-UCL	F	cytokine activity
GO:0031707	IDA:BHF-UCL	F	endothelin A receptor binding
GO:0031708	IDA:BHF-UCL	F	endothelin B receptor binding
GO:0005179	IDA:BHF-UCL	F	hormone activity
GO:0014824	IDA:BHF-UCL	P	artery smooth muscle contraction
GO:0007589	IEA:Ensembl	P	body fluid secretion
GO:0019722	IDA:BHF-UCL	P	calcium-mediated signaling
GO:0051216	IEA:Ensembl	P	cartilage development
GO:0007267	IDA:BHF-UCL	P	cell-cell signaling
GO:0016049	IEA:Ensembl	P	cell growth
GO:0007166	IDA:BHF-UCL	P	cell surface receptor signaling pathway
GO:0071277	IEA:Ensembl	P	cellular response to calcium ion
GO:0035690	IEA:Ensembl	P	cellular response to drug
GO:0071398	IEA:Ensembl	P	cellular response to fatty acid
GO:0071385	IEA:Ensembl	P	cellular response to glucocorticoid stimulus
GO:0071456	IEA:Ensembl	P	cellular response to hypoxia
GO:0071346	IEA:Ensembl	P	cellular response to interferon-gamma
GO:0071347	IEA:Ensembl	P	cellular response to interleukin-1
GO:0071389	IEA:Ensembl	P	cellular response to mineralocorticoid stimulus
GO:0071375	IEA:Ensembl	P	cellular response to peptide hormone stimulus
GO:0071560	IEA:Ensembl	P	cellular response to transforming growth factor beta stimulus
GO:0071356	IEA:Ensembl	P	cellular response to tumor necrosis factor
GO:0009953	IEA:Ensembl	P	dorsal/ventral pattern formation
GO:0042045	IEA:Ensembl	P	epithelial fluid transport
GO:0015758	IEA:Ensembl	P	glucose transport
GO:0007186	IDA:BHF-UCL	P	G-protein coupled receptor signaling pathway
GO:0007507	IEA:Ensembl	P	heart development
GO:0001821	IEA:Ensembl	P	histamine secretion
GO:0048016	IDA:BHF-UCL	P	inositol phosphate-mediated signaling
GO:0001701	IEA:Ensembl	P	in utero embryonic development
GO:0045321	TAS:BHF-UCL	P	leukocyte activation
GO:0060137	IEA:Ensembl	P	maternal process involved in parturition
GO:0051899	IEA:Ensembl	P	membrane depolarization
GO:0042474	IEA:Ensembl	P	middle ear morphogenesis
GO:0010259	IEA:Ensembl	P	multicellular organismal aging
GO:0030195	TAS:BHF-UCL	P	negative regulation of blood coagulation
GO:0030818	IEA:Ensembl	P	negative regulation of cAMP biosynthetic process
GO:0032269	IDA:BHF-UCL	P	negative regulation of cellular protein metabolic process
GO:0046888	IEA:Ensembl	P	negative regulation of hormone secretion
GO:0051771	IDA:BHF-UCL	P	negative regulation of nitric-oxide synthase biosynthetic process
GO:0034392	IEA:Ensembl	P	negative regulation of smooth muscle cell apoptotic process
GO:0000122	IDA:BHF-UCL	P	negative regulation of transcription from RNA polymerase II promoter
GO:0014032	IEA:Ensembl	P	neural crest cell development
GO:0030185	IDA:BHF-UCL	P	nitric oxide transport
GO:0001569	IEA:Ensembl	P	patterning of blood vessels
GO:0030072	IDA:BHF-UCL	P	peptide hormone secretion
GO:0014065	IDA:BHF-UCL	P	phosphatidylinositol 3-kinase signaling
GO:0031583	IEA:Ensembl	P	phospholipase D-activating G-protein coupled receptor signaling pathway
GO:0010613	IDA:BHF-UCL	P	positive regulation of cardiac muscle hypertrophy
GO:0030335	IDA:BHF-UCL	P	positive regulation of cell migration
GO:0008284	IDA:BHF-UCL	P	positive regulation of cell proliferation
GO:0045793	IDA:BHF-UCL	P	positive regulation of cell size
GO:0070101	IC:BHF-UCL	P	positive regulation of chemokine-mediated signaling pathway
GO:0007204	IDA:BHF-UCL	P	positive regulation of cytosolic calcium ion concentration
GO:0051482	IEA:Ensembl	P	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0010595	TAS:BHF-UCL	P	positive regulation of endothelial cell migration
GO:0010460	IDA:BHF-UCL	P	positive regulation of heart rate
GO:0046887	IDA:BHF-UCL	P	positive regulation of hormone secretion
GO:0043507	IDA:BHF-UCL	P	positive regulation of JUN kinase activity
GO:0043406	IDA:BHF-UCL	P	positive regulation of MAP kinase activity
GO:0045840	IDA:BHF-UCL	P	positive regulation of mitosis
GO:0090023	IEA:Ensembl	P	positive regulation of neutrophil chemotaxis
GO:0045429	TAS:BHF-UCL	P	positive regulation of nitric oxide biosynthetic process
GO:0042482	IEA:Ensembl	P	positive regulation of odontogenesis
GO:0060585	IMP:BHF-UCL	P	positive regulation of prostaglandin-endoperoxide synthase activity
GO:0032308	IEA:Ensembl	P	positive regulation of prostaglandin secretion
GO:0010870	IDA:BHF-UCL	P	positive regulation of receptor biosynthetic process
GO:0035815	IEA:Ensembl	P	positive regulation of renal sodium excretion
GO:0060298	IMP:BHF-UCL	P	positive regulation of sarcomere organization
GO:0048661	IDA:BHF-UCL	P	positive regulation of smooth muscle cell proliferation
GO:0045987	IEA:Ensembl	P	positive regulation of smooth muscle contraction
GO:0045944	IEA:Ensembl	P	positive regulation of transcription from RNA polymerase II promoter
GO:0035810	IEA:Ensembl	P	positive regulation of urine volume
GO:0001516	IDA:BHF-UCL	P	prostaglandin biosynthetic process
GO:0007205	IEA:Ensembl	P	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0042313	IDA:BHF-UCL	P	protein kinase C deactivation
GO:0006885	IEA:Ensembl	P	regulation of pH
GO:0051930	IEA:Ensembl	P	regulation of sensory perception of pain
GO:0003100	IDA:BHF-UCL	P	regulation of systemic arterial blood pressure by endothelin
GO:0019229	IEA:InterPro	P	regulation of vasoconstriction
GO:0007585	IEA:Ensembl	P	respiratory gaseous exchange
GO:0014823	IEA:Ensembl	P	response to activity
GO:0043200	IEA:Ensembl	P	response to amino acid
GO:0071548	IEA:Ensembl	P	response to dexamethasone
GO:0044321	IEA:Ensembl	P	response to leptin
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0035994	IEA:Ensembl	P	response to muscle stretch
GO:0035094	IEA:Ensembl	P	response to nicotine
GO:0010193	IEA:Ensembl	P	response to ozone
GO:0034696	IEA:Ensembl	P	response to prostaglandin F
GO:1902074	IEA:Ensembl	P	response to salt
GO:0033574	IEA:Ensembl	P	response to testosterone
GO:0043179	IEA:Ensembl	P	rhythmic excitation
GO:0019233	IEA:Ensembl	P	sensory perception of pain
GO:0042554	IEA:Ensembl	P	superoxide anion generation
GO:0042310	IDA:BHF-UCL	P	vasoconstriction
GO:0014826	IDA:BHF-UCL	P	vein smooth muscle contraction

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_18283	G alpha (q) signalling events
REACT_120966	Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_14819	Peptide ligand-binding receptors
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction