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MGP000916

Record overview

MGPD IDMGP000916
Gene ID1936
SpeciesHomo sapiens (Human)
Gene Nameeukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Gene Symbol EEF1D
SynonymsEF1D; EF-1D; FP1047;
Alternate nameselongation factor 1-delta; EF-1-delta; antigen NY-CO-4; guanine nucleotide exchange protein;
Chromosome8
Map Location8q24.3
SummaryThis gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]
OrthologsView orthologs and multiple alignments for EEF1D

Proteins

elongation factor 1-delta isoform 1
Refseq ID:NP_115754
Protein GI:304555581
UniProt ID:P29692
mRNA ID:NM_032378
Length:647
RefSeq Status:
MRSGKASCTLETVWEDKHKYEEAERRFYEHEATQAAASAQQLPAEGPAMNGPGQDDPEDADEAEAPDGGSRRDPRKSQDSRKPLQKKRKRSPKSGLGPAD
LALLGLSAERVWLDKSLFDQAESSYRQKLADVAAQAAWPPALAPWGLCTHGNQVACHHVTWGIWVNKSSFDQAERAFVEWSQALLLAPEGSRRQGTPNTG
QQVAVPDLAHQPSPPVNGQPPLGSLQALVREVWLEKPRYDAAERGFYEALFDGHPPGKVRLQERAGLAEGARRGRRDRRGRNILGNKRAGLRRADGEAPS
ALPYCYFLQKDAEAPWLSKPAYDSAECRHHAAEALRVAWCLEAASLSHRPGPRSGLSVSSLRPNRKMATNFLAHEKIWFDKFKYDDAERRFYEQMNGPVA
GASRQENGASVILRDIARARENIQKSLAGSSGPGASSGTSGDHGELVVRIASLEVENQSLRGVVQELQQAISKLEARLNVLEKSSPGHRATAPQTQHVSP
MRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQLEACVRSIQLDGLVWGASKLV
PVGYGIRKLQIQCVVEDDKVGTDLLEEEITKFEEHVQSVDIAAFNKI
 
elongation factor 1-delta isoform 1
Refseq ID:NP_001123525
Protein GI:304555583
UniProt ID:P29692
mRNA ID:NM_001130053
Length:647
RefSeq Status:
Protein sequence is identical to GI:304555581 (mRNA isoform)
 
elongation factor 1-delta isoform 2
Refseq ID:NP_001123527
Protein GI:194239727
UniProt ID:P29692
mRNA ID:NM_001130055
Length:281
RefSeq Status:
MATNFLAHEKIWFDKFKYDDAERRFYEQMNGPVAGASRQENGASVILRDIARARENIQKSLAGSSGPGASSGTSGDHGELVVRIASLEVENQSLRGVVQE
LQQAISKLEARLNVLEKSSPGHRATAPQTQHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILL
DVKPWDDETDMAQLEACVRSIQLDGLVWGASKLVPVGYGIRKLQIQCVVEDDKVGTDLLEEEITKFEEHVQSVDIAAFNKI
 
elongation factor 1-delta isoform 2
Refseq ID:NP_001951
Protein GI:25453472
UniProt ID:P29692
mRNA ID:NM_001960
Length:281
RefSeq Status:
Protein sequence is identical to GI:194239727 (mRNA isoform)
 
elongation factor 1-delta isoform 2
Refseq ID:NP_001123529
Protein GI:194239731
UniProt ID:P29692
mRNA ID:NM_001130057
Length:281
RefSeq Status:
Protein sequence is identical to GI:194239727 (mRNA isoform)
 
elongation factor 1-delta isoform 2
Refseq ID:NP_001276879
Protein GI:584458478
UniProt ID:P29692
mRNA ID:NM_001289950
Length:281
RefSeq Status:
Protein sequence is identical to GI:194239727 (mRNA isoform)
 
elongation factor 1-delta isoform 4
Refseq ID:NP_001123528
Protein GI:194239729
UniProt ID:P29692
mRNA ID:NM_001130056
Length:257
RefSeq Status:
MATNFLAHEKIWFDKFKYDDAERRFYEQMNGPVAGASRQSSGPGASSGTSGDHGELVVRIASLEVENQSLRGVVQELQQAISKLEARLNVLEKSSPGHRA
TAPQTQHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQLEACVRSIQLD
GLVWGASKLVPVGYGIRKLQIQCVVEDDKVGTDLLEEEITKFEEHVQSVDIAAFNKI
 
elongation factor 1-delta isoform 5
Refseq ID:NP_001182132
Protein GI:304555588
UniProt ID:P29692
mRNA ID:NM_001195203
Length:262
RefSeq Status:
MATNFLAHEKIWFDKFKYDDAERRFYEQMNGPVAGASRQENGASVILRDIARARENIQKSLAGSSGPGASSGTSGDHVVQELQQAISKLEARLNVLEKSS
PGHRATAPQTQHVSPMRQVEPPAKKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILLDVKPWDDETDMAQLEACVR
SIQLDGLVWGASKLVPVGYGIRKLQIQCVVEDDKVGTDLLEEEITKFEEHVQSVDIAAFNKI
 
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