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MGP000916

UniProt Annotations

Entry Information
Gene Nameeukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Protein EntryEF1D_HUMAN
UniProt IDP29692
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=P29692-1; Sequence=Displayed; Name=2; Synonyms=eEF1BdeltaL; IsoId=P29692-2; Sequence=VSP_037884; Note=Ref.3 (AAP35906), Ref.4 (EAW82228) and Ref.5 (AAH07847) sequences are in conflict in position: 189:D->E. Contains a phosphoserine at position 91. Contains a phosphoserine at position 94. {ECO:0000305}; Name=3; IsoId=P29692-3; Sequence=VSP_043812; Note=Contains a phosphoserine at position 40.; Name=4; IsoId=P29692-4; Sequence=VSP_045960; Note=No experimental confirmation available.;
FunctionIsoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.
FunctionIsoform 2: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).
InductionBy homocysteine (HC), may mediate accelerated synthesis of free thiol-containing proteins in response to HC-induced oxidative stress. Also induced following exposure to ionizing radiation. {ECO:0000269|PubMed:8168075, ECO:0000269|PubMed:9677419}.
InteractionQ5T5U3:ARHGAP21; NbExp=2; IntAct=EBI-358607, EBI-1642518; O95352:ATG7; NbExp=2; IntAct=EBI-358607, EBI-987834; Q08AD1:CAMSAP2; NbExp=2; IntAct=EBI-358607, EBI-1051869; P26641:EEF1G; NbExp=3; IntAct=EBI-358607, EBI-351467;
SimilarityBelongs to the EF-1-beta/EF-1-delta family. {ECO:0000305}.
Subcellular LocationIsoform 2: Nucleus {ECO:0000269|PubMed:21597468}.
SubunitEF-1 is composed of 4 subunits: alpha, beta, delta isoform 1, and gamma. Isoform 2 interacts with HSF1 and NFE2L2.
Tissue SpecificityIsoform 2 is specifically expressed in brain, cerebellum and testis.
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