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MGP000919

Record overview

MGPD IDMGP000919
Gene ID1942
SpeciesHomo sapiens (Human)
Gene Nameephrin-A1
Gene Symbol EFNA1
SynonymsB61; EFL1; ECKLG; EPLG1; LERK1; LERK-1; TNFAIP4;
Alternate namesephrin-A1; TNF alpha-induced protein 4; ligand of eph-related kinase 1; immediate early response protein B61; eph-related receptor tyrosine kinase ligand 1; tumor necrosis factor alpha-induced protein 4; tumor necrosis factor, alpha-induced protein 4;
Chromosome1
Map Location1q21-q22
SummaryThis gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for EFNA1

Proteins

ephrin-A1 isoform a precursor
Refseq ID:NP_004419
Protein GI:33359682
UniProt ID:P20827
mRNA ID:NM_004428
Length:205
RefSeq Status:
MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHG
PEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHDNPQEKRLAADDPEVRVLHSIGHSAAPRLFPLAWTVLLLPLL
LLQTP
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1909
peptide sequence: 
MEFLWAPLLGLCCSLAAA

mat_peptide: 19..205
product: ephrin-A1 isoform a
calculated_mol_wt: 21896
peptide sequence: 
DRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGK
EFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHDNPQEKRLAADDPEVRVLHSIGHSAAPRLFPLAWTVLLLPLLLLQTP
 
ephrin-A1 isoform b precursor
Refseq ID:NP_872626
Protein GI:33359680
UniProt ID:P20827
mRNA ID:NM_182685
Length:183
RefSeq Status:
MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHG
PEKLSEKFQRFTPFTLGKEFKEGHSYYYISHSPQAHDNPQEKRLAADDPEVRVLHSIGHSAAPRLFPLAWTVLLLPLLLLQTP
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1909
peptide sequence: 
MEFLWAPLLGLCCSLAAA

mat_peptide: 19..205
product: ephrin-A1 isoform a
calculated_mol_wt: 21896
peptide sequence: 
DRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGK
EFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHDNPQEKRLAADDPEVRVLHSIGHSAAPRLFPLAWTVLLLPLLLLQTP

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1909
peptide sequence: 
MEFLWAPLLGLCCSLAAA

mat_peptide: 19..183
product: ephrin-A1 isoform b
calculated_mol_wt: 19355
peptide sequence: 
DRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGK
EFKEGHSYYYISHSPQAHDNPQEKRLAADDPEVRVLHSIGHSAAPRLFPLAWTVLLLPLLLLQTP
 
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