MGP Database

MGP000929

Ontology/Pathway Information

Entrez Gene ID	1958
Gene Name	early growth response 1
Gene Symbol	EGR1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	ISS:UniProtKB	C	cytoplasm
GO:0005654	TAS:Reactome	C	nucleoplasm
GO:0005634	ISS:UniProtKB	C	nucleus
GO:0003677	IDA:UniProtKB	F	DNA binding
GO:0003690	IEA:Ensembl	F	double-stranded DNA binding
GO:0035035	IPI:BHF-UCL	F	histone acetyltransferase binding
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0001077	IEA:Ensembl	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0000979	IEA:Ensembl	F	RNA polymerase II core promoter sequence-specific DNA binding
GO:0043565	IDA:UniProtKB	F	sequence-specific DNA binding
GO:0003700	IDA:UniProtKB	F	sequence-specific DNA binding transcription factor activity
GO:0000976	IDA:UniProtKB	F	transcription regulatory region sequence-specific DNA binding
GO:0030509	IEA:Ensembl	P	BMP signaling pathway
GO:0071236	IEA:Ensembl	P	cellular response to antibiotic
GO:0071320	IBA:RefGenome	P	cellular response to cAMP
GO:0035690	IEA:Ensembl	P	cellular response to drug
GO:0071372	IEA:Ensembl	P	cellular response to follicle-stimulating hormone stimulus
GO:0071480	IEA:Ensembl	P	cellular response to gamma radiation
GO:0071371	IBA:RefGenome	P	cellular response to gonadotropin stimulus
GO:0071363	IEA:Ensembl	P	cellular response to growth factor stimulus
GO:0071504	ISS:UniProtKB	P	cellular response to heparin
GO:0071455	IEA:Ensembl	P	cellular response to hyperoxia
GO:0071456	IEA:Ensembl	P	cellular response to hypoxia
GO:0032869	IEA:Ensembl	P	cellular response to insulin stimulus
GO:0071317	IEA:Ensembl	P	cellular response to isoquinoline alkaloid
GO:0071260	IEA:Ensembl	P	cellular response to mechanical stimulus
GO:0071506	ISS:UniProtKB	P	cellular response to mycophenolic acid
GO:0071383	IEA:Ensembl	P	cellular response to steroid hormone stimulus
GO:0007623	IEA:Ensembl	P	circadian rhythm
GO:0019221	TAS:Reactome	P	cytokine-mediated signaling pathway
GO:0072110	ISS:UniProtKB	P	glomerular mesangial cell proliferation
GO:0070498	IMP:BHF-UCL	P	interleukin-1-mediated signaling pathway
GO:0007611	IEA:Ensembl	P	learning or memory
GO:0060291	IEA:Ensembl	P	long-term synaptic potentiation
GO:0043066	IBA:RefGenome	P	negative regulation of apoptotic process
GO:0090090	IEA:Ensembl	P	negative regulation of canonical Wnt signaling pathway
GO:0000122	IEA:Ensembl	P	negative regulation of transcription from RNA polymerase II promoter
GO:0048709	IEA:Ensembl	P	oligodendrocyte differentiation
GO:0072303	ISS:UniProtKB	P	positive regulation of glomerular metanephric mesangial cell proliferation
GO:0043525	IEA:Ensembl	P	positive regulation of neuron apoptotic process
GO:0045893	IDA:UniProtKB	P	positive regulation of transcription, DNA-templated
GO:0045944	IDA:BHF-UCL	P	positive regulation of transcription from RNA polymerase II promoter
GO:0048169	IBA:RefGenome	P	regulation of long-term neuronal synaptic plasticity
GO:0033233	IDA:BHF-UCL	P	regulation of protein sumoylation
GO:0001975	IEA:Ensembl	P	response to amphetamine
GO:0034465	IEA:Ensembl	P	response to carbon monoxide
GO:0042220	IEA:Ensembl	P	response to cocaine
GO:0051602	IEA:Ensembl	P	response to electrical stimulus
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0009749	IEA:Ensembl	P	response to glucose
GO:0071873	IEA:Ensembl	P	response to norepinephrine
GO:0031667	IEA:Ensembl	P	response to nutrient levels
GO:0035914	IBA:RefGenome	P	skeletal muscle cell differentiation
GO:0030217	IEA:Ensembl	P	T cell differentiation
GO:0006366	IDA:BHF-UCL	P	transcription from RNA polymerase II promoter
GO:0060337	TAS:Reactome	P	type I interferon signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_75790	Cytokine Signaling in Immune system
REACT_6900	Immune System
REACT_25162	Interferon alpha/beta signaling
REACT_25229	Interferon Signaling