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MGP000929

UniProt Annotations

Entry Information
Gene Nameearly growth response 1
Protein EntryEGR1_HUMAN
UniProt IDP18146
SpeciesHuman
Comments
Comment typeDescription
FunctionTranscriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation.
InductionBy growth factors.
InteractionQ8N726:CDKN2A; NbExp=4; IntAct=EBI-2834611, EBI-625922; P35222:CTNNB1; NbExp=7; IntAct=EBI-2834611, EBI-491549;
SimilarityBelongs to the EGR C2H2-type zinc-finger protein family. {ECO:0000305}.
SimilarityContains 3 C2H2-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00042}.
Subcellular LocationNucleus.
SubunitInteracts with SNAI1 and SP1 upon 12-O- tetradecanoylphorbol-13-acetate (TPA) induction. {ECO:0000269|PubMed:20121949}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/EGR1ID496ch5q31.html";
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