MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP000935

UniProt Annotations

Entry Information
Gene Nameeukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
Protein EntryIF2G_HUMAN
UniProt IDP41091
SpeciesHuman
Comments
Comment typeDescription
FunctioneIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
InteractionP05198:EIF2S1; NbExp=4; IntAct=EBI-1054228, EBI-1056162; P20042:EIF2S2; NbExp=3; IntAct=EBI-1054228, EBI-711977;
SimilarityBelongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
SimilarityContains 1 tr-type G (guanine nucleotide-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU01059}.
SubunitHeterotrimer composed of an alpha, a beta and a gamma chain.
  logo