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MGP000940

Record overview

MGPD IDMGP000940
Gene ID1977
SpeciesHomo sapiens (Human)
Gene Nameeukaryotic translation initiation factor 4E
Gene Symbol EIF4E
SynonymsCBP; EIF4F; AUTS19; EIF4E1; EIF4EL1;
Alternate nameseukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; eukaryotic translation initiation factor 4E-like 1;
Chromosome4
Map Location4q23
SummaryThe protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
OrthologsView orthologs and multiple alignments for EIF4E

Proteins

eukaryotic translation initiation factor 4E isoform 1
Refseq ID:NP_001959
Protein GI:4503535
UniProt ID:P06730
mRNA ID:NM_001968
Length:217
RefSeq Status:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEP
MWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSH
ADTATKSGSTTKNRFVV
 
eukaryotic translation initiation factor 4E isoform 2
Refseq ID:NP_001124151
Protein GI:194578909
UniProt ID:P06730
mRNA ID:NM_001130679
Length:248
RefSeq Status:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEP
MWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETRWDLAMLPRLVSNFWPQVILPLQPPKVLELQLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTE
CENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
 
eukaryotic translation initiation factor 4E isoform 3
Refseq ID:NP_001124150
Protein GI:194578907
UniProt ID:P06730
mRNA ID:NM_001130678
Length:237
RefSeq Status:
MLDLTSRGQVGTSRRMAEAACSAHFLETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQ
LSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
 
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